KISS1 Gene Polymorphisms in Korean Girls with Central Precocious Puberty
نویسندگان
چکیده
منابع مشابه
KISS1 Gene Polymorphisms in Korean Girls with Central Precocious Puberty
Kisspeptin/G-protein couple receptor-54 (GPR54) system plays a key role in the activation of the gonadotropic axis at puberty. Central precocious puberty (CPP) is caused by the premature activation of hypothalamic gonadotropin-releasing hormone secretion. This study was aimed to identify KISS1 gene variations and to investigate the associations between KISS1 gene variations and CPP in Korean gi...
متن کاملAssociation study of the polymorphisms in the KISS1 gene with central precocious puberty in Chinese girls.
OBJECTIVE The kisspeptin/GPR54 pathway has been proven to be crucial in the process of puberty onset, yet the polymorphisms in the KISS1 gene and their relationships with central precocious puberty (CPP) have not been investigated. This study was performed to reveal the relationship between the gene and the disease. DESIGN AND METHODS 272 Chinese Han girls diagnosed to be CPP patients were re...
متن کاملSerum Kisspeptin Levels in Korean Girls with Central Precocious Puberty
Central precocious puberty (CPP) is caused by premature activation of hypothalamic gonadotropin-releasing hormone (GnRH) secretion. Kisspeptin and G-protein coupled receptor-54 system is the essential gatekeeper of the reproductive system, playing a key role in the activation of the gonadotropic axis at puberty. We aimed to determine whether serum kisspeptin may function as a marker for CPP by ...
متن کاملKISS1 gene analysis in Korean girls with central precocious puberty: a polymorphism, p.P110T, suggested to exert a protective effect.
Mutations in the GPR54 gene have already been identified as a cause of idiopathic hypogonadotrophic hypogonadism and central precocious puberty (CPP) in certain patients. However, currently there is only a limited amount of data available regarding KISS1 gene mutations or polymorphisms. The aim of this study is to identify KISS1 gene mutations or polymorphisms in Korean girls with CPP. 101 Kore...
متن کاملSerum vitamin D levels in girls with central precocious puberty
Precocious puberty can cause several adverse effects on final growth and social behavior in girls. Recently studies showed that low serum vitamin D levels might be associated with precocious puberty. The aim of this research was to investigate the association between serum vitamin D levels and central precocious puberty in girls. Girls with central precocious puberty under the age of 8 we...
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ژورنال
عنوان ژورنال: Journal of Korean Medical Science
سال: 2014
ISSN: 1011-8934,1598-6357
DOI: 10.3346/jkms.2014.29.8.1120